Sickle Cell Anemia:

An inherited blood disorder in which the body produces c-shaped red blood cells. Because of their shape, these cells may stick to each other or to the sides of blood vessels, and cause serious health disorders.



How Sickle Cell Anemia is Inherited:

This disease is inherited by having two genes for sickle hemoglobin. One from each parent. Some people might have one normal gene from one parent and a sickle hemoglobin gene from the other parent. This gives them a condition called sickle cell trait. People with sickle cell trait have very few symptoms and have pretty normal lives. Others could end up with medical problems.

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Signs:

  • Unexplained episodes of severe pain
  • Swelling in hands and feet
  • Abdominal swelling
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  • Pale skin or Nail beds.

Symptoms:

  • Episodes of Pain: Periodic episodes of pain, called crises. Pain develops when the Sickle red blood cell blocks the flow of blood through tiny blood vessels to your chest,abdomen, and joints.

  • Hand-Foot symdrome: Swollen hands and feet way be the first signs of sickle cell anemia in babies, It's caused by blockage of blood through the hands and feet.

  • Frequent infection: Damage your spleen, and organs that fight infection. This may make you more vulnerable to infections. Doctors commonly give infants and children with Sickle cell anemia antibiotics to prevent potenially life-threatening infections, such as pneumonia.

  • Delayed growth: Red blood cells provide your body with thye oxygen and nutrients you need for growth. A shortageof healthy red blood cells can slow growth in infants and childer and delay puberty in teenager

  • Vision problem: Some people with Sickle cell anemia experiences vision problems. Tiny blood vessels that supply your eyes may become plugged with Sickle cells, This can damage the retina- the portion of the eye that processes visual images.

Interesting Facts:

  • The life expectancy for men with Sickle Cell Anemia is 42 years old, women is 48 years old.
  • About 1 out of every 500 African-American babies born in the United States have Sickle Cell Anemia.
  • Not like normal Red blood cells, which can live for 120 days, Sickle shaped cells live only 10 and 20 days

Treatments:

Treatments are designed to relieve pain and to prevent infections, organ damage and strokes.
  • Hydroxyurea
-makes body create fetal hemoglobin (hemoglobin F)
-helps to keep blood cells from sickling
- Reduces acute attacks
- May help growth and preserve organ function
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  • Blood and marrow stem cell transplants
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  • Antibiotics
  • Over-the-Counter medicines
-relieves pain
  • Other New Medicines
-Decitabine
-like Hydroxyurea
-Adenosine A2a receptor agonists
-reduces pain
-5-HMF
-prevents blood from sickling


Works Cited
" Healthy Living looks at living with anemia | Channel5Belize.com ." Channel5Belize.com | News 5 Live . N.p., n.d. Web. 28 Feb. 2012. <http://edition.channel5belize.com/archives>.
"How Is Sickle Cell Anemia Treated? - NHLBI, NIH." NIH Heart, Lung and Blood Institute. N.p., n.d. Web. 2 Mar. 2012. http://www.nhlbi.nih.gov/health/health-topics/topics/sca/treatment.html.
"Sickle cell anemia: Symptoms - MayoClinic.com." Mayo Clinic. N.p., n.d. Web. 2 Mar. 2012. <http://www.mayoclinic.com/health/sickle-cell-anemia/DS00324/DSECTION=symptoms>.
"Sickle Cell Disease and Sickle Cell Trait ." Texas Department of State Health Services. N.p., n.d. Web. 28 Feb. 2012. www.dshs.state.tx.us/newborn/celltrai.shtm.

"Sickle cell anemia, causes." NIH Heart, Lung and Blood Institute. N.p., n.d. Web. 2 Mar. 2012. <http://www.nhlbi.nih.gov/health//dci/Diseases/Sca/SCA_causes.html>.