Duchenne Muscular Dystrophy:

Affects 1 in 3600 boys
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Duchenne Muscular Dystrophy is caused by a mutation of the dystrophin gene, located on the X-chromosome.
A person with Duchenne doesn't produce dystrophin, which provides struture to cell membranes.
external image 19097.jpgDuchenne ussually apears by age 5, a child with it is in a wheelchair by age 12, and they die by age 25.
This type of Muscular Dystrophy also exists in dogs.







Inheritace
Females can be affected, but very rarely are because a man doesn't ussally pass it on. A girl must get it from both parents to be affected by it, but a boy only needs to get it from his mother. More often, the woman is a carrier, which means she has the mutation, but it does not show. She can still pass it on, however. A boy has XY chromosomes. The X is from the mother and the Y is from the father. Since Muscular Dystrophy is a mutation on the X chromosome, it is passed from the mother to the son. Since a girl is XX, she must have gotten X from both parents. To have Duchenne, you must have it on both X's so the mutation must exist in both parents for a girl to be effected.

Sources
"Duchenne muscular dystrophy - Wikipedia, the free encyclopedia." Wikipedia, the free encyclopedia. N.p., n.d. Web. 23 Feb. 2012. <http://en.wikipedia.org/wiki/Duchenne

"Researchers Develop DNA 'Patch' For Canine Form of Muscular Dystrophy." National Institutes of Health: News and Events 16 Mar. 2009. Student Resources in Context. Web. 28 Feb. 2012.
Symptoms
The disease causes serious inhibitions in the muscular system, and is characterized by rapid deterioration of muscle groups. The area afected as well as speed of progression varys between cases, but ultimately ends the same; those affected will die from it eventually. the progression of muscle deterioration will start from week muscles, as the patient grows, their muscles will shrink. many people with this disease lose operation of their legs as the muscle tissue breaks down, and eventualy they cannot walk.

Treatment
Currently, there is no cure for this disease, however, there are treatments that willslow the prosses down. Probably the most effective is a cordicosteiroid, an artifical replacment for the absent enzyme, in this case dystrophen, that will hold the muscle together, but this treatment is very expensive, and again will only slow the deterioration.

Signs
Only a doctor can proporly diagnose this disease, but there are some warning signs to look for. frequent falls, dificulty jumpng and running are a few of them, a waddling gait is also indicative of this. There have also been cases of mental retardation, but that isnt exclusive, or entirely indicative